NUR 641E WK7 DQ1 Paper

NUR 641E WK7 DQ1 Paper

Delirium is a neurological disorder common to the ICU. It is a tragic occurrence that affects more than 80 percent of adult vital care patients. Initial diagnosis and care are required to reduce the signs and symptoms of the disorder. Delirium is correlated with prolonged stays in the ICU, additional need for a ventilator, and elevated risk of mortality. According to McCance & Huether (2018), delirium is often referred to as an intense condition of uncertainty and describes it as intermittent disorders of consciousness that can have a rapid slow emergence. NUR 641E WK7 DQ1 Paper

Delirium is triggered by neural network instability. It includes the reticular stimulation of the upper brain and thalamus, the basal ganglion, and the particular associated sections of the cortex and limbic regions. Numerous neurotransmitters are as well involved. There is a reduction of acetylcholine or melatonin and a rise of excretion of dopamine, glutamate, or norepinephrine. Other chemicals are also produced, such as cytokines, serotonin, and tumor alpha necrosis aspect (Mainerova et al., 2015). Many of these chemicals are believed to affect the permeability of the blood-brain obstacle, inducing oxidative stress, modifying brain blood supply, and stimulating microglia, both of which impair neurotransmission and resulting neurobehavior and cognitive effects (McCance & Huether, 2018). NUR 641E WK7 DQ1 Paper


There are some measures a nurse may do to reduce the rate of delirium or the severity of the incident. One of the forms that this will happen is by fostering a peaceful and welcoming atmosphere. Sedated patients may also maintain a sense of understanding, because where changes are rendered (like lights are kept on high all the time or no agglomeration care) disruptions may lead to the degradation of the neural network.


Mainerova, B., Prasko, J., Latalova, K., Axmann, K., Cerna, M., Horacek, R., & Bradacova, R. (2015). Alcohol withdrawal delirium-diagnosis, course and treatment. Biomedical Papers of the Medical Faculty of Palacky University in Olomouc159(1).

McCance, K. L., & Huether, S. E. (2018). Pathophysiology-E-book: the biologic basis for disease in adults and children. Elsevier Health Sciences. NUR 641E WK7 DQ1 Paper