Critical Appraisal of Research in Evidence-Based Practice or EBP

Critical Appraisal of Research in Evidence-Based Practice or EBP

he Assignment (Evidence-Based Project) Part 3A: Critical Appraisal of Research Conduct a critical appraisal of the four peer-reviewed articles you selected by completing the Evaluation Table within the Critical Appraisal Tool Worksheet Template. Choose a total of four peer- reviewed articles that you selected related to your clinical topic of interest in Module 2 and Module 3. Note: You can choose any combination of articles from Modules 2 and 3 for your Critical Appraisal. For example, you may choose two unfiltered research articles from Module 2 and two filtered research articles (systematic reviews) from Module 3 or one article from Module 2 and three articles from Module 3. You can choose any combination of articles from the prior Module Assignments as long as both modules and types of studies are represented. Part 3B: Critical Appraisal of Research Based on your appraisal, in a 1-2-page critical appraisal, suggest a best practice that emerges from the research you reviewed. Briefly explain the best practice, justifying your proposal with APA citations of the research. Critical Appraisal of Research in Evidence-Based Practice or EBP.

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Part A: Critical Appraisal of Research (Matrix)

Full APA formatted citation of selected article. Article #1 Article #2 Article #3 Article #4
Andriani, Y., & Nadjib, M. (2018). The importance of implementation of hand hygiene practice in reducing healthcare-associated infections: A systematic review. The 2nd International Conference on Hospital Administration (KnE Life Sciences),135–145. https://doi.org/10.18502/kls.v4i9.3565

 

Borren, N.Z., Ghadermarzi, S., Hutfless, S., & Ananthakrishnan, A.N. (2017). The emergence of Clostridium difficile infection in Asia: A systematic review and meta-analysis of incidence and impact. PLOS ONE, 12(5), 1-16. https:// doi.org/10.1371/journal.pone.0176797

 

Freeman, M.C., Stocks, M.E., Cumming, O., Jeandron, A., Higgins, J.P.T., Wolf, J., Prüss-Ustün, A., Bonjour, S., Hunter, P.R., Fewtrell, L., & Curtis, V. (2014). Hygiene and health: Systematic review of handwashing practices worldwide and update of health effects. Tropical Medicine & International Health, 19(8), 906–916. https://doi.org/10.1111/tmi.12339 Gerding, D.N., Muto, C.A., & Owens Jr, R.C. (2008). Measures to control and prevent Clostridium difficile infection. Clinical Infectious Diseases46(Supplement 1), S43-S49. http://dx.doi.org/10.1086/521861

 

Evidence Level *

(I, II, or III)

 

Level I Level I Level I Level II
Conceptual Framework

Describe the theoretical basis for the study (If there is not one mentioned in the article, say that here).**

Implied: Washing hands with soap and water will effectively dislodge microbial particles by dissolving lipid bonds. Critical Appraisal of Research in Evidence-Based Practice or EBP.

 

Implied: Resistant strains of bacteria develop this ability after repeated exposures to antibiotics. Implied: handwashing will reduce the population of microbes on the hands and reduce the chances of developing diarrheal diseases. Implied: Clostridium difficile populations are high in hospital environments and the hands of healthcare employees.
Design/Method

Describe the design and how the study was carried out (In detail, including inclusion/exclusion criteria).

Systematic review with PRISMA method.

Article inclusion was publication within the last 10 years.

Systematic review and meta-analysis.

Inclusion was publication in the last 10 years.

 

Systematic review Quantitative study.
Sample/Setting

The number and characteristics of

patients, attrition rate, etc.

Sample: n = 11 articles

Setting: Electronic database search

Sample: n = 51 studies and 37,663 patients

Setting: Electronic databases

Sample: n = 42 studies

Setting: Databases

Sample: All admitted patients

Setting: The hospital

Major Variables Studied

List and define dependent and independent variables

Independent variable: Handwashing with soap and water.

Dependent variable: Infection with HAIs.

 

Independent variable: Antibiotic use.

Dependent variable: Development of resistant strains of CD.

Independent variable: Handwashing

Dependent variable: Diarrheal diseases.

Independent variable: Handwashing.

Dependent variable: Development of CDI.

Measurement

Identify primary statistics used to answer clinical questions (You need to list the actual tests done).

The PRISMA model. Random effects meta-analysis and pooled prevalence. Multi-level modelling and meta-regression Reduction of CDI related to use of Na hypochlorite solution (p <0.5)
Data Analysis Statistical or

Qualitative findings

(You need to enter the actual numbers determined by the statistical tests or qualitative data).

Handwashing with soap and water associated with low rates of HAIs. 5.3 CD episodes per 10,000 patient days.CDI mortality = 8.9%. ·         19% of world population washes hands with soap

·         Handwashing lowers the risk of contracting diarrheal disease by 40%.

·         10% Na hypochlorite reduces CD populations in the environment

·         Handwashing with chlorhexidine is effective in lowering CDI rates

Findings and Recommendations

General findings and recommendations of the research

There was a reduction in the number of those infected with HAIs when hand hygiene was implemented.

Frequent handwashing is recommended for the prevention of HAIs.

CDI is a HAI with significant mortality risk. Handwashing with soap and water is effective in reducing diarrheal infections including HAIs.

Routine handwashing is an important public health measure.

Handwashing with either chlorhexidine or soap and water plus environmental cleaning with Na hypochlorite prevents infections with CD.
Appraisal and Study Quality

Describe the general worth of this research to practice.

What are the strengths and limitations of study?

What are the risks associated with implementation of the suggested practices or processes detailed in the research?

What is the feasibility of use in your practice?

He research is important in increasing EBP knowledge.

The strength is that a systematic review provides the highest level of evidence. The limitation is that it is not primary research. Critical Appraisal of Research in Evidence-Based Practice or EBP.

There are no risks associated with handwashing.

Handwashing is very feasible in the community and healthcare settings.

The research is important for improvement of clinical practice.

The strength is in the high level of evidence while the weakness is in not being primary research.

The risk of antibiotic stewardship is that a deserving patient may be denied antibiotic prescription for fear of resistance.

The feasibility of the recommendations is good. They are practical.

 

 

The study adds to EBP knowledge.

The strength is in the evidentiary value. The limitation is not being primary research.

There are no known risks of practicing handwashing.

It is highly feasible to apply the findings.

The study is an important source of EBP information.

It is weak as it has secondary information. The strength is in specificity of recommendations (chlorhexidine and 10% Na hypochlorite).

The risks include wrong dilution ratios resulting in corrosion of surfaces and also poisoning from accidental ingestion.

The recommendations are feasible.

 

Key findings

Handwashing with soap and water prevents HAIs. There are significantly high rates of HAIs. Handwashing reduces infection with diarrheal diseases. Handwashing and cleaning the environment reduce CDI.
Outcomes Reduced rates of HAIs. Increased rates of CDI mortality. Lowered rates of diarrheal HAIs. Low CDI rates.
General Notes/Comments The article builds on the knowledge available for evidence-based practice or EBP. The findings are bound to change clinical practice. The findings build EBP. The article enriches EBP.

 

 

Part B: Critical Appraisal of Research Narrative

From the critical appraisal of evidence above, there are several interventions that can be described as best practice that emerge. These practices are evidence-based because they have been tried and tested by way of research. Furthermore, this scholarly research has been peer-reviewed and published in reputed journals. Three of these four studies reviewed are systematic reviews and meta-analyses. In the pyramid of evidence, systematic reviews and meta-analyses provide the highest level of evidence that is needed (level 1) to prove that an intervention is indeed efficacious. For this reason, the following best practice in the form of practice recommendations has the best possible evidence that supports their inclusion into evidence-based practice protocols. The best practice recommendations that emerge are:

  • The practice of regular handwashing with soap and water is an effective measure that reduces the rate of infection with hospital-acquired infections or HAIs (Andriani & Nadjib, 2018). This systematic review found that handwashing on a regular basis is a cost-effective way to prevent healthcare-associated infections (HAIs). This is what nurses must do regularly in practice. Critical Appraisal of Research in Evidence-Based Practice or EBP.
  • There are significantly increased infections with Clostridium difficile (CD), resulting in high mortality. Handwashing with soap and water has proved effective in preventing this scenario (Borren et al., 2017). CD is one of the most resistant strains of bacteria and a leading cause of HAIs. Handwashing with soap and water in developing countries was found to effective at preventing its spread.
  • Handwashing reduces the incidence of diarrheal diseases (Freeman et al., 2014).
  • Handwashing with chlorhexidine and environmental cleaning with 10% Na hypochlorite solution reduces CDI HAIs significantly (Gerding et al., 2008). Of all the three studies, this one is the most specific in terms of the chemical agents that can be used to battle Clostridium difficile infection as a HAI in hospitals.

References

Andriani, Y., & Nadjib, M. (2018). The importance of implementation of hand hygiene practice in reducing healthcare-associated infections: A systematic review. The 2nd International Conference on Hospital Administration (KnE Life Sciences),135–145. https://doi.org/10.18502/kls.v4i9.3565

Borren, N.Z., Ghadermarzi, S., Hutfless, S., & Ananthakrishnan, A.N. (2017). The emergence of Clostridium difficile infection in Asia: A systematic review and meta-analysis of incidence and impact. PLOS ONE, 12(5), 1-16. https:// doi.org/10.1371/journal.pone.0176797

Freeman, M.C., Stocks, M.E., Cumming, O., Jeandron, A., Higgins, J.P.T., Wolf, J., Prüss-Ustün, A., Bonjour, S., Hunter, P.R., Fewtrell, L., & Curtis, V. (2014). Hygiene and health: Systematic review of handwashing practices worldwide and update of health effects. Tropical Medicine & International Health, 19(8), 906–916. https://doi.org/10.1111/tmi.12339. Critical Appraisal of Research in Evidence-Based Practice or EBP.

Gerding, D.N., Muto, C.A., & Owens Jr, R.C. (2008). Measures to control and prevent Clostridium difficile infection. Clinical Infectious Diseases46(Supplement 1), S43-S49. http://dx.doi.org/10.1086/521861

Melnyk, B.M., & Fineout-Overholt, E. (2019). Evidence-based practice in nursing & healthcare: A guide to best practice, 4th ed. Wolters Kluwer.

Use this document to complete the evaluation table requirement of the Module 4 Assessment, Evidence-Based Project, Part 4A: Critical Appraisal of Research

 

 

Full APA formatted citation of selected article. Article #1 Article #2 Article #3 Article #4
 

 

 

 

     
Evidence Level *

(I, II, or III)

 

       
Conceptual Framework

 

Describe the theoretical basis for the study (If there is not one mentioned in the article, say that here).**

 

 

 

 

 

     
Design/Method

 

Describe the design and how the study was carried out (In detail, including inclusion/exclusion criteria).

       
Sample/Setting

 

The number and characteristics of

patients, attrition rate, etc.

 

 

 

 

 

     
Major Variables Studied

 

List and define dependent and independent variables

 

 

     
Measurement

 

Identify primary statistics used to answer clinical questions (You need to list the actual tests done).

       
Data Analysis Statistical or

Qualitative findings

 

(You need to enter the actual numbers determined by the statistical tests or qualitative data).

       
Findings and Recommendations

 

General findings and recommendations of the research

       
Appraisal and Study Quality

 

 

Describe the general worth of this research to practice.

 

What are the strengths and limitations of study?

 

What are the risks associated with implementation of the suggested practices or processes detailed in the research?

 

What is the feasibility of use in your practice? Critical Appraisal of Research in Evidence-Based Practice or EBP.

       
 

 

Key findings

 

 

 

       
 

 

Outcomes

 

 

 

       
General Notes/Comments  

 

 

 

 

 

     

 

*These levels are from the Johns Hopkins Nursing Evidence-Based Practice: Evidence Level and Quality Guide

 

  • Level I

Experimental, randomized controlled trial (RCT), systematic review RTCs with or without meta-analysis

 

  • Level II

Quasi-experimental studies, systematic review of a combination of RCTs and quasi-experimental studies, or quasi-experimental studies only, with or without meta-analysis

 

  • Level III

Nonexperimental, systematic review of RCTs, quasi-experimental with/without meta-analysis, qualitative, qualitative systematic review with/without meta-synthesis

  • Level IV

Respected authorities’ opinions, nationally recognized expert committee/consensus panel reports based on scientific evidence

  • Level V

Literature reviews, quality improvement, program evaluation, financial evaluation, case reports, nationally recognized expert(s) opinion based on experiential evidence

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**Note on Conceptual Framework

  • The following information is from Walden academic guides which helps explain conceptual frameworks and the reasons they are used in research. Here is the link https://academicguides.waldenu.edu/library/conceptualframework
  • Researchers create theoretical and conceptual frameworks that include a philosophical and methodological model to help design their work. A formal theory provides context for the outcome of the events conducted in the research. The data collection and analysis are also based on the theoretical and conceptual framework. Critical Appraisal of Research in Evidence-Based Practice or EBP.
  • As stated by Grant and Osanloo (2014), “Without a theoretical framework, the structure and vision for a study is unclear, much like a house that cannot be constructed without a blueprint. By contrast, a research plan that contains a theoretical framework allows the dissertation study to be strong and structured with an organized flow from one chapter to the next.”

 

  • Theoretical and conceptual frameworks provide evidence of academic standards and procedure. They also offer an explanation of why the study is pertinent and how the researcher expects to fill the gap in the literature.
  • Literature does not always clearly delineate between a theoretical or conceptual framework. With that being said, there are slight differences between the two.

References

The Johns Hopkins Hospital/Johns Hopkins University (n.d.). Johns Hopkins nursing dvidence-based practice: appendix C: evidence level and quality guide. Retrieved October 23, 2019 from https://www.hopkinsmedicine.org/evidence-based-practice/_docs/appendix_c_evidence_level_quality_guide.pdf

 

Grant, C., & Osanloo, A. (2014). Understanding, Selecting, and Integrating a Theoretical Framework in Dissertation Research: Creating the Blueprint for Your” House”. Administrative Issues Journal: Education, Practice, and Research, 4(2), 12-26.

Walden University Academic Guides (n.d.). Conceptual & theoretical frameworks overview. Retrieved October 23, 2019 from https://academicguides.waldenu.edu/library/conceptualframework. Critical Appraisal of Research in Evidence-Based Practice or EBP.